Synthelis provides a solution to a well known challenge in terms of biotechnological production – namely the synthesized production of membrane proteins. Around 30% of the human genome is coded for protein membranes. This family of proteins is involved in key biological processes such as cellular signaling, energy transduction or metabolic transportation. Anomalies affecting their structure or function can be directly or indirectly linked to a large number of pathologies. Consequently these molecules are the target for a large number of medicines currently planned for development. The significant difficulties associated with their production, purification and crystallization in comparison with soluble proteins demonstrates the necessity for developing new manufacturing processes. Using a cutting-edge process, Synthelis produces functional membrane proteins in soluble or proteoliposome form. These membrane proteins can be used in structural studies or functional/electrophysiological studies, the development of vaccines or even high throughput molecule/ligand screening.
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